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Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp. Xy24.
J Asian Nat Prod Res ; 19(10): 1028-1035, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28145126
ABSTRACT
A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 µM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 µM, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC50 values of 11.1 and 17.7 µM, respectively.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Esteroides / Trichoderma / Glucosídeos Limite: Humanos Idioma: Inglês Revista: J Asian Nat Prod Res Assunto da revista: Botânica / Química Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: China