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The efficacy of mycophenolate mofetil in treating Takayasu arteritis: a systematic review and meta-analysis.
Rheumatol Int ; 37(7): 1083-1088, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28364217
ABSTRACT
The purpose of this study is to assess the effectiveness of mycophenolate mofetil (MMF) in treating Takayasu arteritis (TA) patients. Embase, Cochrane Library, Pubmed, Clinicaltrials. Gov and three Chinese literature databases (VIP, CNKI, WanFang) were searched; randomized-controlled trials and observational studies that compared the efficacy before and after treatment with MMF were included. The efficacy outcomes were disease activity, the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values and steroid dosage. The results were expressed as mean differences with 95% confidence intervals. Compared with the baseline, there were significant reductions in the ESR (-14.92 [25.35, -4.48]), CRP values (-12.99 [-23.29, -2.68]) and the steroid dosage (-17.64 [-24.89, -10.4]) after the addition of MMF, and the disease tended to stabilize. Therefore, MMF might be an alternative immunosuppressive drug for TA for the control of disease activity and to taper the steroid dosage.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Arterite de Takayasu / Imunossupressores / Ácido Micofenólico Tipo de estudo: Revisão sistemática Aspecto clínico: Terapia Limite: Adolescente / Adulto / Feminino / Humanos / Masculino / Jovem adulto Idioma: Inglês Revista: Rheumatol Int Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: China