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Multi-Förster Resonance Energy Transfer-Based Fluorescent Probe for Spatiotemporal Matrix Metalloproteinase-2 and Caspase-3 Imaging.
Anal Chem ; 89(8): 4349-4354, 2017 04 18.
Artigo em Inglês | MEDLINE | ID: mdl-28365980
ABSTRACT
A novel single-molecular fluorescent probe was developed for spatiotemporal matrix metalloproteinase-2 (MMP-2) and caspase-3 imaging with distinct fluorescence signals. Due to the multi-Förster resonance energy transfer (FRET) processes, the probe could respond to MMP-2 and caspase-3 independently with high signal-to-noise ratio. Moreover, the overexpression of MMP-2 in cancer cell lines and the cisplatin induced cell apoptosis were spatiotemporal imaged with distinct fluorescence emissions. Because of the independent process of the probe for MMP-2 and caspase-3 imaging, the probe could meet the demands for precise disease diagnosis and cancer theranostic applications, which could extensively simplify the processes for precise cancer diagnosis and imaging.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Metaloproteinase 2 da Matriz / Transferência Ressonante de Energia de Fluorescência / Caspase 3 / Corantes Fluorescentes Limite: Animais / Humanos Idioma: Inglês Revista: Anal Chem Ano de publicação: 2017 Tipo de documento: Artigo