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Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners.
Arq Bras Cardiol ; 108(3): 212-216, 2017 Mar.
Artigo em Português, Inglês | MEDLINE | ID: mdl-28443964


The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored.


Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls.


Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before.


As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups.


Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Corrida / Plaquetas / Micropartículas Derivadas de Células / Atletas / Células Progenitoras Endoteliais Limite: Feminino / Humanos / Masculino Idioma: Inglês / Português Revista: Arq Bras Cardiol Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil