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Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners.
Arq Bras Cardiol ; 108(3): 212-216, 2017 Mar.
Artigo em Português, Inglês | MEDLINE | ID: mdl-28443964
RESUMO

BACKGROUND:

The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored.

OBJECTIVE:

Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls.

METHODS:

Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before.

RESULTS:

As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups.

CONCLUSION:

Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Corrida / Plaquetas / Micropartículas Derivadas de Células / Atletas / Células Progenitoras Endoteliais Limite: Feminino / Humanos / Masculino Idioma: Inglês / Português Revista: Arq Bras Cardiol Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil