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Chitosan-palmitic acid based polymeric micelles as promising carrier for circumventing pharmacokinetic and drug delivery concerns of tamoxifen.
Int J Biol Macromol ; 102: 1220-1225, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28483602
Being a BCS class II drug and a good substrate for microsomal enzymes, tamoxifen (TAM) offers a scope for research owing to poor aqueous solubility and compromised bioavailability. The present study designs a novel copolymer derived from palmitic acid and chitosan, and evaluate the derived TAM-loaded micelles for various delivery attributes. The nanometric micellar carriers not only substantially loaded the drug, but also controlled the rate of release of TAM. The designed nanocarrier significantly enhanced the cytotoxicity of TAM on MCF-7 cancer cells. The developed system was designed for intravenous route and was observed to be substantially haemo-compatible with an enhancement of approx. 5 times in AUC vis-a-vis plain drug. The findings employing new polymer-based carrier are promising in nature for the better delivery of similar drugs.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Polímeros / Tamoxifeno / Portadores de Fármacos / Ácido Palmítico / Quitosana / Micelas Limite: Animais / Humanos Idioma: Inglês Revista: Int J Biol Macromol Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Índia