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GABA promotes elastin synthesis and elastin fiber formation in normal human dermal fibroblasts (HDFs).
Uehara, Eriko; Hokazono, Hideki; Hida, Mariko; Sasaki, Takako; Yoshioka, Hidekatsu; Matsuo, Noritaka.
Afiliação
  • Uehara E; a Sanwa Shurui Co., Ltd. , Usa , Japan.
  • Hokazono H; a Sanwa Shurui Co., Ltd. , Usa , Japan.
  • Hida M; b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
  • Sasaki T; b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
  • Yoshioka H; b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
  • Matsuo N; b Faculty of Medicine, Department of Matrix Medicine , Oita University , Yufu , Japan.
Biosci Biotechnol Biochem ; 81(6): 1198-1205, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28485217
ABSTRACT
The multiple physiological effects of γ-aminobutyric acid (GABA) as a functional food component have been recently reported. We previously reported that GABA upregulated the expression of type I collagen in human dermal fibroblasts (HDFs), and that oral administration of GABA significantly increased skin elasticity. However, details of the regulatory mechanism still remain unknown. In this study, we further examined the effects of GABA on elastin synthesis and elastin fiber formation in HDFs. Real-time PCR indicated that GABA significantly increased the expression of tropoelastin transcript in a dose-dependent manner. Additionally, the expression of fibrillin-1, fibrillin-2, and fibulin-5/DANCE, but not lysyl oxidase and latent transforming factor-ß-binding protein 4, were also significantly increased in HDFs. Finally, immunohistochemical analysis confirmed that treatment with GABA dramatically increased the formation of elastic fibers in HDFs. Taken together, our results showed that GABA improves skin elasticity in HDFs by upregulating elastin synthesis and elastin fiber formation.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Elastina / Tropoelastina / Tecido Elástico / Fibroblastos / Ácido gama-Aminobutírico Limite: Humanos Idioma: Inglês Revista: Biosci Biotechnol Biochem Assunto da revista: Bioquímica / Biotecnologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Japão

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Elastina / Tropoelastina / Tecido Elástico / Fibroblastos / Ácido gama-Aminobutírico Limite: Humanos Idioma: Inglês Revista: Biosci Biotechnol Biochem Assunto da revista: Bioquímica / Biotecnologia Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Japão
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