Significance of pregnancy test false negative results due to elevated levels of ß-core fragment hCG.
J Immunoassay Immunochem
; 38(4): 449-455, 2017.
Article
em En
| MEDLINE
| ID: mdl-28521601
ABSTRACT
Very high levels of ß-core fragment human chorionic gonadotrophin (ßcf-hCG) are reported to potentially cause false negative results in point-of-care (POC)/over-the-counter (OTC) pregnancy tests. To investigate this further, women's daily early morning urine samples, collected prior to conception and during pregnancy, were analysed for intact, free ß-, and ßcf-hCG. The proportion of ßcf-hCG was found to be related to that of hCG produced and in circulation. Therefore, best practice for accuracy testing of POC/OTC pregnancy tests would be to test devices against clinical samples containing high levels of ßcf-hCG as well as standards spiked with biologically relevant ratios.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes de Gravidez
/
Gonadotropina Coriônica
Tipo de estudo:
Guideline
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Immunoassay Immunochem
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido