HBK-14 and HBK-15, triple 5-HT1A, 5-HT7 and 5-HT3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice.

Pytka, Karolina; Socala, Katarzyna; Rapacz, Anna; Nieoczym, Dorota; Pieróg, Mateusz; Grybos, Anna; Siwek, Agata; Waszkielewicz, Anna; Wlaz, Piotr

HBK-14 and HBK-15, triple 5-HT_1A, 5-HT₇ and 5-HT₃ antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice.

Pytka, Karolina; Socala, Katarzyna; Rapacz, Anna; Nieoczym, Dorota; Pieróg, Mateusz; Grybos, Anna; Siwek, Agata; Waszkielewicz, Anna; Wlaz, Piotr.

Afiliação

Pytka K; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland. Electronic address: karolina.pytka@uj.edu.pl.
Socala K; Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Lublin, Poland.
Rapacz A; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Nieoczym D; Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Lublin, Poland.
Pieróg M; Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Lublin, Poland.
Grybos A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Siwek A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Waszkielewicz A; Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Wlaz P; Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Sklodowska University, Lublin, Poland.

Prog Neuropsychopharmacol Biol Psychiatry ; 79(Pt B): 378-385, 2017 10 03.

Article em En | MEDLINE | ID: mdl-28729118

Assuntos

Anticonvulsivantes/farmacologia; Éteres Fenílicos/farmacologia; Piperazinas/farmacologia; Convulsões/tratamento farmacológico; Antagonistas da Serotonina/farmacologia; Animais; Ansiolíticos/farmacologia; Antidepressivos/farmacologia; Modelos Animais de Doenças; Eletrochoque; Masculino; Camundongos; Atividade Motora/efeitos dos fármacos; Força Muscular/efeitos dos fármacos; Pentilenotetrazol; Estimulação Luminosa; Distribuição Aleatória; Receptor 5-HT1A de Serotonina/metabolismo; Receptores de Serotonina/metabolismo; Receptores 5-HT3 de Serotonina/metabolismo; Convulsões/metabolismo; Canais de Sódio Disparados por Voltagem/metabolismo

Palavras-chave

5-HT(1A) receptor antagonist; 5-HT(3) receptor antagonist; 5-HT(7) receptor antagonist; Mice; Seizure threshold

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Éteres Fenílicos / Piperazinas / Convulsões / Antagonistas da Serotonina / Anticonvulsivantes Limite: Animals Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido

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