Your browser doesn't support javascript.
Vγ4 γδ T Cells Provide an Early Source of IL-17A and Accelerate Skin Graft Rejection.
J Invest Dermatol ; 137(12): 2513-2522, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28733202
Activated γδ T cells have been shown to accelerate allograft rejection. However, the precise role of skin-resident γδ T cells and their subsets-Vγ5 (epidermis), Vγ1, and Vγ4 (dermis)-in skin graft rejection have not been identified. Here, using a male to female skin transplantation model, we demonstrated that Vγ4 T cells, rather than Vγ1 or Vγ5 T cells, accelerated skin graft rejection and that IL-17A was essential for Vγ4 T-cell-mediated skin graft rejection. Moreover, we found that Vγ4 T cells were required for early IL-17A production in the transplanted area, both in skin grafts and in the host epidermis around grafts. Additionally, the chemokine (C-C motif) ligand 20-chemokine receptor 6 pathway was essential for recruitment of Vγ4 T cells to the transplantation area, whereas both IL-1ß and IL-23 induced IL-17A production from infiltrating cells. Lastly, Vγ4 T-cell-derived IL-17A promoted the accumulation of mature dendritic cells in draining lymph nodes to subsequently regulate αß T-cell function after skin graft transplantation. Taken together, our data reveal that Vγ4 T cells accelerate skin graft rejection by providing an early source of IL-17A.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Transplante de Pele / Receptores de Antígenos de Linfócitos T gama-delta / Interleucina-17 / Rejeição de Enxerto Limite: Animais Idioma: Inglês Revista: J Invest Dermatol Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: China