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Effectiveness evaluation of mood disorder treatment algorithms in Brazilian public healthcare patients.
Braz J Psychiatry ; 40(1): 26-34, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28832750


To assess the effectiveness of three mood disorder treatment algorithms in a sample of patients seeking care in the Brazilian public healthcare system.


A randomized pragmatic trial was conducted with an algorithm developed for treating episodes of major depressive disorder (MDD), bipolar depressive episodes and mixed episodes of bipolar disorder (BD).


The sample consisted of 259 subjects diagnosed with BD or MDD (DSM-IV-TR). After the onset of symptoms, the first treatment occurred ∼6 years and the use of mood stabilizers began ∼12 years. All proposed algorithms were effective, with response rates around 80%. The majority of the subjects took 20 weeks to obtain a therapeutic response.


The algorithms were effective with the medications available through the Brazilian Unified Health System. Because therapeutic response was achieved in most subjects by 20 weeks, a follow-up period longer than 12 weeks may be required to confirm adequate response to treatment. Remission of symptoms is still the main desired outcome. Subjects who achieved remission recovered more rapidly and remained more stable over time.CLINICAL TRIAL REGISTRATION: NCT02901249, NCT02870283, NCT02918097.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Antipsicóticos / Transtorno Bipolar / Transtornos do Humor / Transtorno Depressivo Maior Tipo de estudo: Evaluation_studies Aspecto clínico: Terapia Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Braz J Psychiatry Assunto da revista: Psiquiatria Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Brasil