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Confocal laser feedback tomography for skin cancer detection.
Biomed Opt Express ; 8(9): 4037-4048, 2017 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-28966845
ABSTRACT
Tomographic imaging of soft tissue such as skin has a potential role in cancer detection. The penetration of infrared wavelengths makes a confocal approach based on laser feedback interferometry feasible. We present a compact system using a semiconductor laser as both transmitter and receiver. Numerical and physical models based on the known optical properties of keratinocyte cancers were developed. We validated the technique on three phantoms containing macro-structural changes in optical properties. Experimental results were in agreement with numerical simulations and structural changes were evident which would permit discrimination of healthy tissue and tumour. Furthermore, cancer type discrimination was also able to be visualized using this imaging technique.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Biomed Opt Express Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Austrália