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DNA Methylation and Birth Weight: a Genome-wide Analysis.
Biomed Environ Sci ; 30(9): 667-670, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29081341
ABSTRACT
The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite-converted DNA. We have identified many differentially methylated CpG sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin-signaling pathway (ISP), adipocytokine signaling pathway (ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes..
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Peso ao Nascer / Metilação de DNA / Estudo de Associação Genômica Ampla Limite: Feminino / Humanos / Masculino / Recém-Nascido / Gravidez Idioma: Inglês Revista: Biomed Environ Sci Assunto da revista: Saúde Ambiental Ano de publicação: 2017 Tipo de documento: Artigo