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Quadrivalent inactivated influenza vaccine (VaxigripTetra™).
Expert Rev Vaccines ; 17(1): 1-11, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29157068
ABSTRACT

INTRODUCTION:

VaxigripTetra™ (IIV4; Sanofi Pasteur) is a quadrivalent split-virion influenza vaccine approved in Europe in 2016 for individuals ≥ 3 years of age. IIV4 builds on the well-established record of the trivalent split-virion influenza vaccine (Vaxigrip®).Areas covered: This literature review summarizes the rationale for developing quadrivalent influenza vaccines and discusses the phase III clinical trial results supporting the immunogenicity, safety, and tolerability of IIV4.Expert commentary: IIV4 is immunogenic and well tolerated. Adding a second B strain to the trivalent split-virion influenza vaccine provides a superior immune response for the additional strain but does not reduce the immune response for the three other strains or negatively affect the safety profile. By offering broader protection against co-circulating influenza B lineages, IIV4 has the potential to further reduce influenza-related morbidity and mortality beyond that achieved with trivalent vaccines.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Vírus da Influenza B / Vacinas contra Influenza / Influenza Humana Limite: Humanos Idioma: Inglês Revista: Expert Rev Vaccines Assunto da revista: Alergia e Imunologia Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: França