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Hyperpigmentation of hard palate induced by chloroquine therapy.
de Andrade, Bruno-Augusto-Benevenuto; Padron-Alvarado, Nelson-Alejandro; Muñoz-Campos, Edgar-Manuel; Morais, Thayná-Melo-de Lima; Martinez-Pedraza, Ricardo.
Afiliação
  • de Andrade BA; DDS, PhD, Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
  • Padron-Alvarado NA; DDS, Oral Pathology, Universidad de Carabobo, School of Dentistry, Valencia, Venezuela.
  • Muñoz-Campos EM; DDS, Oral Surgery, University of Montemorelos, School of Dentistry, Montemorelos, NL, Mexico.
  • Morais TL; DDS, Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
  • Martinez-Pedraza R; DDS, Oral Pathology, Universidad Autónoma de Nuevo León, School of Dentistry, Monterrey, NL, Mexico.
J Clin Exp Dent ; 9(12): e1487-e1491, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29410767
ABSTRACT
The antimalarials are one of the most commonly prescribed drugs for conditions such as lupus erythematosus and rheumatoid arthritis, and the side effects, though infrequent, are well known. The antimalarial agent chloroquine diphosphate usually causes pigmentary changes in the oral mucosa characterized by a bluish-grey to black discolorations mainly in the hard palate. Considering only the hard palate hyperpigmentation caused by chloroquine, to the best of our knowledge, only 13 cases have been reported in the English language literature. We described an additional case of palate hyperpigmentation related to the chronic use of chloroquine diphosphate in a 60-year-old Mexican woman. Although the diagnosis is usually made based on medication history and clinical presentation, a biopsy specimen may be helpful to confirm the diagnosis. Clinicians must be aware of these drugs and their adverse effects in order to make the correct diagnosis and decide on the optimal treatment for the condition. Key wordsOral cavity, hard palate, hyperpigmentation, chloroquine, antimalarials.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Relato de casos Idioma: Inglês Revista: J Clin Exp Dent Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Relato de casos Idioma: Inglês Revista: J Clin Exp Dent Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Brasil