Lessons Learned from Luminous Luciferins and Latent Luciferases.
ACS Chem Biol
; 13(7): 1734-1740, 2018 07 20.
Article
em En
| MEDLINE
| ID: mdl-29439568
ABSTRACT
Compared to the broad palette of fluorescent molecules, there are relatively few structures that are competent to support bioluminescence. Here, we focus on recent advances in the development of luminogenic substrates for firefly luciferase. The scope of this light-emitting chemistry has been found to extend well beyond the natural substrate and to include enzymes incapable of luciferase activity with d-luciferin. The broadening range of luciferin analogues and evolving insight into the bioluminescent reaction offer new opportunities for the construction of powerful optical reporters of use in live cells and animals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Luciferina de Vaga-Lumes
/
Luciferases de Vaga-Lume
Limite:
Animals
/
Humans
Idioma:
En
Revista:
ACS Chem Biol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos