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Enhanced gastric retention and drug release via development of novel floating microspheres based on Eudragit E100 and polycaprolactone: synthesis and in vitro evaluation.
Farooq, Umar; Khan, Samiullah; Nawaz, Shahid; Ranjha, Nazar Mohammad; Haider, Malik Salman; Khan, Muhammad Muzamil; Dar, Eshwa; Nawaz, Ahmad.
Afiliação
  • Farooq U; Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Khan S; Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • Nawaz S; Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Ranjha NM; Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Haider MS; Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Khan MM; Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Dar E; Islam College of Pharmacy, Sialkot, Pakistan.
  • Nawaz A; Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
Des Monomers Polym ; 20(1): 419-433, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29491813
ABSTRACT
Eudragit E 100 and polycaprolactone (PCL) floating microspheres for enhanced gastric retention and drug release were successfully prepared by oil in water solvent evaporation method. Metronidazole benzoate, an anti-protozoal drug, was used as a model drug. Polyvinyl alcohol was used as an emulsifier. The prepared microspheres were observed for % recovery, % degree of hydration, % water uptake, % drug loading, % buoyancy and % drug release. The physico-chemical properties of the microspheres were studied by calculating encapsulation efficiency of microspheres and drug release kinetics. Drug release characteristics of microspheres were studied in simulated gastric fluid and simulated intestinal fluid i.e., at pH 1.2 and 7.4 respectively. Fourier transform infrared spectroscopy was used to reveal the chemical interaction between drug and polymers. Scanning electron microscopy was conducted to study the morphology of the synthesized microspheres.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Des Monomers Polym Ano de publicação: 2017 Tipo de documento: Artigo País de afiliação: Paquistão