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Anti-Xa activity in oral factor Xa inhibitor-treated patients with atrial fibrillation and a higher risk of bleeding: a pilot study.
Blood Coagul Fibrinolysis ; 29(4): 369-373, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29538002
ABSTRACT
The number of patients with nonvalvular atrial fibrillation (NV-AF) who require long-term anticoagulation and also have a higher risk of bleeding is increasing. Recently, there is no information regarding real on-treatment anti-Xa activity in patients with NV-AF and a higher risk of bleeding who receive oral factor Xa inhibitors. The aim of this study was to determine trough and peak anti-Xa activity in these patients. This single-centre pilot study enrolled 41 patients with NV-AF and a higher risk of bleeding defined as Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly score at least 3 points. Twenty-one patients were treated with rivaroxaban and 17 patients were treated with apixaban. The trough and peak samples of these patients were tested for anti-Xa activity with factor Xa-calibrated anti-Xa chromogenic analysis. The detected trough anti-Xa activity was 63.2 ±â€Š44.4 ng/ml. There was a significant increase in peak anti-Xa activity up to 170.3 ±â€Š99.6 ng/ml (P < 0.001) observed. There were no significant differences in trough (52.4 ±â€Š41.9 vs. 76.0 ±â€Š45.4 ng/ml; P = 0.12) and peak (187.2 ±â€Š122.5 vs. 151.5 ±â€Š64.0 ng/ml; P = 0.27) anti-Xa activity between rivaroxaban-treated and apixaban-treated patients. This study demonstrated the anti-Xa activity in oral factor Xa inhibitor-treated patients with NV-AF and a higher risk of bleeding. No significant differences in this activity between rivaroxaban-treated and apixaban-treated patients were found.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Fator Xa / Inibidores do Fator Xa / Hemorragia Aspecto clínico: Etiologia / Terapia Limite: Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Blood Coagul Fibrinolysis Assunto da revista: Angiologia / Hematologia Ano de publicação: 2018 Tipo de documento: Artigo