Evaluation of Spironolactone Solid Dispersions Prepared by Co-Spray Drying With Soluplus<sup>®</sup> and Polyvinylpyrrolidone and Influence of Tableting on Drug Release.

Al-Zoubi, Nizar; Odah, Faten; Obeidat, Wasfy; Al-Jaberi, Ahmad; Partheniadis, Ioannis; Nikolakakis, Ioannis

Evaluation of Spironolactone Solid Dispersions Prepared by Co-Spray Drying With Soluplus^® and Polyvinylpyrrolidone and Influence of Tableting on Drug Release.

Al-Zoubi, Nizar; Odah, Faten; Obeidat, Wasfy; Al-Jaberi, Ahmad; Partheniadis, Ioannis; Nikolakakis, Ioannis.

Afiliação

Al-Zoubi N; Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan. Electronic address: nzoubi@hu.edu.jo.
Odah F; Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
Obeidat W; Department of Pharmaceutical Technology, Jordan University of Science and Technology, Irbid, Jordan.
Al-Jaberi A; Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
Partheniadis I; Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.
Nikolakakis I; Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. Electronic address: yannikos@pharm.auth.gr.

J Pharm Sci ; 107(9): 2385-2398, 2018 09.

Article em En | MEDLINE | ID: mdl-29752945

Assuntos

Química Farmacêutica/métodos; Liberação Controlada de Fármacos; Polietilenoglicóis/síntese química; Polivinil/síntese química; Povidona/síntese química; Espironolactona/síntese química; Avaliação Pré-Clínica de Medicamentos/métodos; Excipientes Farmacêuticos/síntese química; Excipientes Farmacêuticos/farmacocinética; Polietilenoglicóis/farmacocinética; Polivinil/farmacocinética; Povidona/farmacocinética; Espectroscopia de Infravermelho com Transformada de Fourier/métodos; Espironolactona/farmacocinética; Comprimidos; Difração de Raios X/métodos

Palavras-chave

X-ray diffractometry; amorphicity; dissolution; solid dispersion; solubility; spray drying; thermal analysis; vibration spectroscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polivinil / Espironolactona / Química Farmacêutica / Povidona / Liberação Controlada de Fármacos Tipo de estudo: Prognostic_studies Idioma: En Revista: J Pharm Sci Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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