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Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging.
Aging (Albany NY) ; 10(5): 868-901, 2018 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-29779015
ABSTRACT
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Encefalopatias / Envelhecimento / Processamento de Proteína Pós-Traducional / Estresse Oxidativo Limite: Animais / Humanos Idioma: Inglês Revista: Aging (Albany NY) Assunto da revista: Geriatria Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Grécia