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A systematic review of paediatric deep venous thrombolysis.
Phlebology ; 34(3): 179-190, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29860923
ABSTRACT

OBJECTIVES:

The aim was to assess the effectiveness and safety of catheter-directed thrombolysis in children with deep venous thrombosis and to evaluate its long-term effect. METHOD AND

RESULTS:

EMBASE, Medline and Cochrane databases were searched to identify studies in which paediatric acute deep venous thrombosis patients received thrombolysis. Following title and abstract screening, seven cohort studies with a total of 183 patients were identified. Technical success was 82% and superior in regional rather than systemic thrombolysis (p < 0.00001). One cohort study identified significant difference in thrombus resolution at one year between thrombolytic and anticoagulant groups (p = 0.01). The complication rate was low, with incidence rates of major bleeding, pulmonary embolism and others at 2.8%, 1.8% and 8.4%, respectively. The overall post-thrombotic syndrome rate was 12.7%. The incidence of re-thrombosis ranged from 12.3% to 27%.

CONCLUSION:

Thrombolysis for paediatric deep venous thrombosis is an effective and relatively safe therapeutic option, lowering the incidence of post-thrombotic syndrome and deep venous thrombosis recurrence.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Terapia Trombolítica / Trombose Venosa / Anticoagulantes Tipo de estudo: Revisão sistemática Aspecto clínico: Etiologia / Terapia Limite: Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Phlebology Assunto da revista: Angiologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Reino Unido