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A systematic review of paediatric deep venous thrombolysis.
Phlebology ; 34(3): 179-190, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29860923


The aim was to assess the effectiveness and safety of catheter-directed thrombolysis in children with deep venous thrombosis and to evaluate its long-term effect. METHOD AND


EMBASE, Medline and Cochrane databases were searched to identify studies in which paediatric acute deep venous thrombosis patients received thrombolysis. Following title and abstract screening, seven cohort studies with a total of 183 patients were identified. Technical success was 82% and superior in regional rather than systemic thrombolysis (p < 0.00001). One cohort study identified significant difference in thrombus resolution at one year between thrombolytic and anticoagulant groups (p = 0.01). The complication rate was low, with incidence rates of major bleeding, pulmonary embolism and others at 2.8%, 1.8% and 8.4%, respectively. The overall post-thrombotic syndrome rate was 12.7%. The incidence of re-thrombosis ranged from 12.3% to 27%.


Thrombolysis for paediatric deep venous thrombosis is an effective and relatively safe therapeutic option, lowering the incidence of post-thrombotic syndrome and deep venous thrombosis recurrence.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Terapia Trombolítica / Trombose Venosa / Anticoagulantes Tipo de estudo: Revisão sistemática Aspecto clínico: Etiologia / Terapia Limite: Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Phlebology Assunto da revista: Angiologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Reino Unido