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Stage III should be subclassified into Stage IIIA and IIIB in the American Joint Committee on Cancer (8th Edition) staging system for pancreatic cancer.
World J Gastroenterol ; 24(22): 2400-2405, 2018 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-29904247
ABSTRACT

AIM:

To ascertain the prognostic role of the T4 and N2 category in stage III pancreatic cancer according to the 8th edition of the American Joint Committee on Cancer (AJCC) classification.

METHODS:

Patients were collected from the Surveillance Epidemiology and End Results (SEER) database (2004-2013) and were divided into three groups: T(1-3)N2, T4N(0-1), and T4N2. Overall survival (OS) and disease-specific survival (DSS) of patients were evaluated by the Kaplan-Meier method.

RESULTS:

For the first time, we found a significant difference in OS and DSS between T(1-3)N2/T4N(0-1) and T4N2 but not between T(1-3)N2 and T4N(0-1). A higher grading correlated with a worse prognosis in the T(1-3)N2 and T4N2 groups.

CONCLUSION:

Patients with stage T4N2 had a worse prognosis than those with stage T(1-3)N2/T4N(0-1) in the 8th edition AJCC staging system for pancreatic cancer. We recommend that stage III should be subclassified into stage IIIA [T(1-3)N2/T4N(0-1)] and stage IIIB (T4N2).
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Programa de SEER Aspecto clínico: Prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade / Jovem adulto Idioma: Inglês Revista: World J Gastroenterol Assunto da revista: Gastroenterologia Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China