The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides.

Petchey, Mark; Cuetos, Anibal; Rowlinson, Benjamin; Dannevald, Stephanie; Frese, Amina; Sutton, Peter W; Lovelock, Sarah; Lloyd, Richard C; Fairlamb, Ian J S; Grogan, Gideon

Petchey, Mark; Cuetos, Anibal; Rowlinson, Benjamin; Dannevald, Stephanie; Frese, Amina; Sutton, Peter W; Lovelock, Sarah; Lloyd, Richard C; Fairlamb, Ian J S; Grogan, Gideon.

Afiliação

Petchey M; Department of Chemistry, University of York, York, YO10 5DD, UK.
Cuetos A; Department of Chemistry, University of York, York, YO10 5DD, UK.
Rowlinson B; Department of Chemistry, University of York, York, YO10 5DD, UK.
Dannevald S; Department of Chemistry, University of York, York, YO10 5DD, UK.
Frese A; Department of Chemistry, University of York, York, YO10 5DD, UK.
Sutton PW; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Lovelock S; Current address: Department of Chemical, Biological and Environmental Engineering, Bioprocess Engineering and Applied Biocatalysis Group, Engineering School, Campus de la UAB, 08193 Bellaterra (Cerdanyola del Vallés), Barcelona, Spain.
Lloyd RC; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Fairlamb IJS; Current address: School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN, UK.
Grogan G; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.

Angew Chem Int Ed Engl ; 57(36): 11584-11588, 2018 09 03.

Article em En | MEDLINE | ID: mdl-30035356

Assuntos

Complexos de ATP Sintetase/metabolismo; Actinomycetales/metabolismo; Amidas/metabolismo; Proteínas de Bactérias/metabolismo; Carbolinas/metabolismo; Complexos de ATP Sintetase/química; Actinomycetales/química; Actinomycetales/enzimologia; Amidas/química; Proteínas de Bactérias/química; Vias Biossintéticas; Carbolinas/química; Domínio Catalítico; Modelos Moleculares; Metabolismo Secundário; Especificidade por Substrato

Palavras-chave

ATP; adenylation; amides; biocatalysis; ligases

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Actinomycetales / Carbolinas / Complexos de ATP Sintetase / Amidas Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Alemanha

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