Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.

Roelants, Caroline; Giacosa, Sofia; Pillet, Catherine; Bussat, Rémi; Champelovier, Pierre; Bastien, Olivier; Guyon, Laurent; Arnoux, Valentin; Cochet, Claude; Filhol, Odile

Roelants, Caroline; Giacosa, Sofia; Pillet, Catherine; Bussat, Rémi; Champelovier, Pierre; Bastien, Olivier; Guyon, Laurent; Arnoux, Valentin; Cochet, Claude; Filhol, Odile.

Afiliação

Roelants C; Université Grenoble-Alpes, Inserm U1036, CEA, BIG-BCI, Grenoble, France.
Giacosa S; Inovarion, Paris, France.
Pillet C; Université Grenoble-Alpes, Inserm U1036, CEA, BIG-BCI, Grenoble, France.
Bussat R; Université Grenoble-Alpes, Inserm U1038, CEA, BIG-BGE, Grenoble, France.
Champelovier P; Université Grenoble-Alpes, Inserm U1036, CEA, BIG-BCI, Grenoble, France.
Bastien O; Centre Hospitalier Université Grenoble-Alpes, CS 10217, Grenoble, France.
Guyon L; Université Grenoble-Alpes, CNRS-CEA-INRA, Laboratoire de Physiologie Cellulaire et Végétale, Grenoble, France.
Arnoux V; Université Grenoble-Alpes, Inserm U1036, CEA, BIG-BCI, Grenoble, France.
Cochet C; Centre Hospitalier Université Grenoble-Alpes, CS 10217, Grenoble, France.
Filhol O; Université Grenoble-Alpes, Inserm U1036, CEA, BIG-BCI, Grenoble, France.

Oncotarget ; 9(53): 30066-30078, 2018 Jul 10.

Article em En | MEDLINE | ID: mdl-30046388

Palavras-chave

3D culture; kidney cancer; protein kinase; synthetic lethality; targeted combinational therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Oncotarget Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos

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