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Protective Effect of Hesperidin on Sodium Arsenite-Induced Nephrotoxicity and Hepatotoxicity in Rats.
Turk, Erdinç; Kandemir, Fatih Mehmet; Yildirim, Serkan; Caglayan, Cuneyt; Kucukler, Sefa; Kuzu, Muslum.
Afiliação
  • Turk E; Department of Pharmacy Professional Sciences, Faculty of Pharmacy, Agri Ibrahim Cecen University, 04100, Agri, Turkey. eturk@agri.edu.tr.
  • Kandemir FM; Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
  • Yildirim S; Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
  • Caglayan C; Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, Bingol, Turkey.
  • Kucukler S; Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
  • Kuzu M; Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Agri Ibrahim Cecen University, Agri, Turkey.
Biol Trace Elem Res ; 189(1): 95-108, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30066062
ABSTRACT
The present study was conducted to investigate the protective effects of hesperidin (HSP) against sodium arsenite (SA)-induced nephrotoxicity and hepatotoxicity in rats. Thirty-five male Sprague Dawley rats were divided into five groups as follows control, HSP, SA, SA + HSP 100, and SA + HSP 200. Rats were orally gavaged with SA (10 mg/kg body weight) and HSP (100 and 200 mg/kg body weight) for 15 days. SA increased oxidative damage by decreasing antioxidant enzyme activities, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and glutathione (GSH) level and increasing malondialdehyde (MDA) level in the kidney and liver tissues. In addition, it increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities and serum urea and creatinine levels. Furthermore, SA caused inflammation, apoptosis, and oxidative DNA damage by increasing tumor necrosis factor-α (TNF-α), nuclear factor kappa B (NF-κB), interleukin-1ß (IL-1ß), cysteine aspartate-specific protease-3 (caspase-3), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the kidney and liver tissues and by increasing liver p53 and kidney interleukin-6 (IL-6) expressions. In other words, HSP administration reduced apoptosis, oxidative stress, inflammation, and oxidative DNA damage significantly in SA-induced kidney and liver tissues depending on dose. In this study, it was seen that HSP showed a protective effect against SA-induced kidney and liver toxicity.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Compostos de Sódio / Arsenitos / Hesperidina / Rim Limite: Animais Idioma: Inglês Revista: Biol Trace Elem Res Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Turquia