Your browser doesn't support javascript.
Identification of adenovirus neutralizing antigens using capsid chimeric viruses.
Virus Res ; 256: 100-106, 2018 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-30096411
ABSTRACT
Human adenoviruses (HAdV) 3 and 7 can cause acute respiratory disease epidemics and outbreaks. Identification of neutralizing epitopes is vital for surveillance and vaccine development. In this study, we generated the recombinant capsid-chimeric human adenoviruses rAd3E-Fk7, containing the Ad3E backbone and the HAdV-7 fiber knob, and rAd3E-H7Fk7, which contain an Ad3E backbone but HAdV-7 hexon and fiber knob. In vitro neutralization tests with these chimeric adenoviruses using both mouse and human antisera indicated that hexon and fiber knob are the major targets recognized by neutralizing antibodies against HAdV-3 or HAdV-7, and other capsid proteins including the penton base and fiber shaft may not contribute to neutralizing antibody responses. In conclusion, both hexon and fiber knob structures in HAdV-3 and HAdV-7 may be the proteins which induce neutralizing antibody responses and thus may be important for adenovirus vaccine and drug development.
Assuntos

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Recombinação Genética / Adenovírus Humanos / Proteínas do Capsídeo / Anticorpos Neutralizantes / Anticorpos Antivirais Limite: Animais / Humanos Idioma: Inglês Revista: Virus Res Assunto da revista: Virologia Ano de publicação: 2018 Tipo de documento: Artigo