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Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats1.
Acta Cir Bras ; 33(7): 609-618, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30110062


To investigate the gastroprotective effect of methanol extract of E. spectabilis and its major component isoorientin.


Effects of isoorientin and methanol extract of E. spectabilis were investigated in indomethacin-induced gastric damage model on rats. Famotidine was used as the standard antiulcer drug. Numerical density of ulcer areas and oxidative status were determined on stomach tissues of rats.


All doses of isoorientin and methanol extract decreased MDA level and increased SOD activity and GSH levels in the stomach tissue of rats. When numerical density of ulcer areas were analized, the 500 mg/kg dose of methanol extract (84%) exhibited a similar effect to 20 mg/kg dose of standart drug famotidine (87%).


The gastroprotective effects of E. spectabilis and its major constituent isoorientin in rats for the first time. Detailed analyses suggested that potential antioxidant activity of both plant extract and isoorientin mediates the gastroprotective effect.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Úlcera Gástrica / Extratos Vegetais / Luteolina / Metanol / Xanthorrhoeaceae / Antiulcerosos / Antioxidantes Limite: Animais Idioma: Inglês Revista: Acta Cir Bras Ano de publicação: 2018 Tipo de documento: Artigo