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Acid suppressant medications and the risk of allergic diseases.
Expert Rev Clin Immunol ; 14(9): 771-780, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30113236
ABSTRACT

INTRODUCTION:

Acid suppressant medications (ASMs), such as proton pump inhibitors and histamine-2 receptor antagonists, are used often and throughout the lifespan. These medications have been linked to the development of a variety of allergic diseases. Areas covered This review discusses prior studies investigating the association between acid ASM exposure and the development of allergic diseases. We performed a thorough literature search to identify potentially relevant studies for inclusion. In summary, exposure to these medications prenatally, in childhood and in adulthood, may increase the risk of allergic diseases. The current evidence is limited by primarily observational study design and potential bias and confounding. The mechanism of action is not yet known, but there are several proposed theories. Expert commentary There is a growing body of evidence to support that exposure to acid ASMs increases the risk of developing allergic diseases. Further research is needed to not only clarify this relationship but to define the potential mechanism of action. If further research confirms these observations, we believe that could warrant changes in the patterns of prescribing and use of acid ASMs.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Refluxo Gastroesofágico / Antialérgicos / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Inibidores da Bomba de Prótons / Antagonistas dos Receptores Histamínicos / Hipersensibilidade Aspecto clínico: Etiologia / Terapia Limite: Adolescente / Adulto / Feminino / Humanos / Gravidez Idioma: Inglês Revista: Expert Rev Clin Immunol Assunto da revista: Alergia e Imunologia Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Estados Unidos