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What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?
Sao Paulo Med J ; 136(5): 472-478, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30365598
ABSTRACT

BACKGROUND:

The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach.

DESIGN AND SETTING:

Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP).

METHODS:

A broad search was conducted in the Cochrane Database of Systematic Reviews to retrieve any Cochrane SRs that assessed the efficacy and safety of cannabinoids as a therapeutic approach. The results and key characteristics of all reviews included were summarized and discussed.

RESULTS:

Eight SRs were included. They assessed the use of cannabinoids for the following types of conditions: neurological (two SRs), psychiatric (two SRs), rheumatological (one SR), infectious (one SR) and oncological (two SRs). There was moderate-quality evidence showing that the use of cannabinoids reduced nausea and vomiting among adults, compared with placebo. Additionally, there was moderate-quality evidence showing that there was no difference between cannabinoids and prochlorperazine regarding the number of participants who reported vomiting, in this same population.

CONCLUSIONS:

This review identified eight Cochrane systematic reviews that provided evidence of unknown to moderate quality regarding the use of cannabinoids as a therapeutic intervention. Further studies are still imperative for solid conclusions to be reached regarding practical recommendations.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Canabinoides / Revisão Sistemática como Assunto Tipo de estudo: Broad_synthesis / Revisão sistemática Aspecto clínico: Terapia Limite: Humanos Idioma: Inglês Revista: Sao Paulo Med J Assunto da revista: Medicina Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Brasil