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Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma.
Aly, Ashraf A; El-Sheref, Essmat M; Bakheet, Momtaz E M; Mourad, Mai A E; Bräse, Stefan; Ibrahim, Mahmoud A A; Nieger, Martin; Garvalov, Boyan K; Dalby, Kevin N; Kaoud, Tamer S.
Afiliação
  • Aly AA; Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt. Electronic address: ashrafaly63@yahoo.com.
  • El-Sheref EM; Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt.
  • Bakheet MEM; Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt.
  • Mourad MAE; Medicinal Chemistry Department, Faculty of Pharmacy, Port-Said University, Port-Said 42526, Egypt.
  • Bräse S; Institute of Toxikology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz Platz 1, Campus Nord, 76344 Eggenstein-Leopoldshafen, Germany; Institute of Toxikologie und Genetik, Hermann-von-Helmholtz Platz 1, Campus Nord, 76344 Eggenstein-Leopoldshafen, Germany.
  • Ibrahim MAA; Chemistry Department, Faculty of Science, Minia University, 61519 El-Minia, Egypt.
  • Nieger M; Department of Chemistry, University of Helsinki, PO Box 55 (A. I. Virtasen aukio I), 00014 University of Helsinki, Finland.
  • Garvalov BK; Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
  • Dalby KN; Division of Chemical Biology and Medicinal Chemistry, The University of Texas at Austin, Austin, TX 78712, USA.
  • Kaoud TS; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519 El Minia, Egypt; Division of Chemical Biology and Medicinal Chemistry, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: tkaood1@utexas.edu.
Bioorg Chem ; 82: 290-305, 2019 02.
Article em En | MEDLINE | ID: mdl-30396063
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Quinolonas / Proteína Quinase 1 Ativada por Mitógeno / Proteína Quinase 3 Ativada por Mitógeno / Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Quinolonas / Proteína Quinase 1 Ativada por Mitógeno / Proteína Quinase 3 Ativada por Mitógeno / Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos