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Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment.
Pharmacogenomics ; 19(18): 1403-1412, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30479191
ABSTRACT

AIM:

Mucositis, linked to methotrexate, daunorubicin or cyclophosphamide, is a frequent childhood acute lymphoblastic leukemia (ALL) therapy side effect. miRNAs regulate the expression of pharmacokinetic/pharmacodynamic pathway genes. SNPs in miRNAs could affect their levels or function, and affect their pharmacokinetic/pharmacodynamic pathway target genes. Our aim was to determine the association between miRNA genetic variants targeting mucositis-related genes and mucositis-developing risk. PATIENTS & METHODS: We analyzed 160 SNPs in 179 Spanish children with B-cell precursor ALL homogeneously treated with LAL/SHOP protocols.

RESULTS:

We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively.

CONCLUSION:

The effect of these SNPs on genes related to drug pharmacokinetics/pharmacodynamics could explain mucositis, diarrhea and vomiting development during ALL therapy.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / MicroRNAs / Mucosite / Leucemia-Linfoma Linfoblástico de Células Precursoras Aspecto clínico: Etiologia Limite: Criança, pré-escolar / Feminino / Humanos / Masculino Idioma: Inglês Revista: Pharmacogenomics Assunto da revista: Farmacologia / Genética Médica Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: Espanha