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[Study on fragmentation pathways of three ginkgolides by mass spectrometry].
Zhongguo Zhong Yao Za Zhi ; 43(20): 4093-4096, 2018 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-30486536
ABSTRACT
The fragmentation pathways of the three ginkgolides (ginkgolides A, ginkgolides B, ginkgolides C) have been studied with high resolution and high mass accuracy using quadrupole time-of-flight mass spectrometry in negative ion mode in this paper. The results indicate that the three ginkgolides have similar fragmentation pathways, including four kinds of common cleavage pathways and one common characteristic ion. In high quality regions, the typical fragmentation pathways of the three ginkgolides are lactone ring opening with continuous loss of CO, CO2,and loss of H2O. In low quality regions, the common characteristic fragment ion of the three ginkgolides at m/z72.993 6 is formed by C rings cleavage. Also, the common fragment ions of ginkgolides A and ginkgolides B at m/z141.018 8, 125.023 8, 113.024 0, 97.029 1 are formed by A rings cleavage. The study of fragmentation pathways could be adopted for the structural identification of the ginkgolides and their metabolites.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Ginkgolídeos Idioma: Chinês Revista: Zhongguo Zhong Yao Za Zhi Assunto da revista: Farmacologia / Terapias Complementares Ano de publicação: 2018 Tipo de documento: Artigo País de afiliação: China