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The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans.
Psychiatry Res ; 270: 775-779, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30551324
ABSTRACT
Several studies have established that Major depressive disorder is associated with excess inflammation with an elevation of both pro and anti-inflammatory cytokines in major depressive disorder. In addition, individuals with major depressive disorder are at higher risk of developing coronary artery disease. The role of innate immunity and NFκB-mediated inflammation in depression and its increased association with coronary artery disease is yet to be fully elucidated. Polymorphisms in the Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat and Pyrin Domain Containing 12 (NLRP12), are associated with depression and coronary artery disease in trauma exposed individuals. In a cohort of Vietnam War veterans (n = 299) NLRP12 polymorphisms were analysed for association with depression and coronary calcium scores. The NLRP12 polymorphism, rs34436714 was associated with a higher DASS21 Score for depression (p = 0.037). NLRP12 polymorphisms rs34971363 and rs6509825 (p = 0.022 and p = 0.020) were associated with raised coronary calcium score. To our knowledge, this is the first time rs34436714 has been investigated in Vietnam veterans identifying AC as a risk genotype for depression in Caucasian cohorts. It is also the first time the rs34971363 (CG) and rs6509825 (CT) genotype have been associated with raised coronary calcium score.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Veteranos / Doença da Artéria Coronariana / Distúrbios de Guerra / Peptídeos e Proteínas de Sinalização Intracelular / Transtorno Depressivo Maior / Inflamassomos / Genótipo Tipo de estudo: Estudo de coorte Aspecto clínico: Etiologia Limite: Humanos / Masculino Idioma: Inglês Revista: Psychiatry Res Ano de publicação: 2018 Tipo de documento: Artigo