Identification of novel Kv1.3 targeting venom peptides by a single round of autocrine-based selection.

Liu, Yaohui; Zhang, Jiashuo; Wang, Ruikun; Wu, Yaxing; Wang, Wei; Xin, Xiu; Du, Mingjuan; Cao, Youjia; Zhang, Hongkai

Liu, Yaohui; Zhang, Jiashuo; Wang, Ruikun; Wu, Yaxing; Wang, Wei; Xin, Xiu; Du, Mingjuan; Cao, Youjia; Zhang, Hongkai.

Afiliação

Liu Y; State Key Laboratory of Medicinal Chemical Biology, 94 Weijin Road, Tianjin, 300071, China; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Zhang J; State Key Laboratory of Medicinal Chemical Biology, 94 Weijin Road, Tianjin, 300071, China; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Wang R; State Key Laboratory of Medicinal Chemical Biology, 94 Weijin Road, Tianjin, 300071, China; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Wu Y; State Key Laboratory of Medicinal Chemical Biology, 94 Weijin Road, Tianjin, 300071, China; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Wang W; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China.
Xin X; State Key Laboratory of Medicinal Chemical Biology, 94 Weijin Road, Tianjin, 300071, China; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Du M; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China. Electronic address: dumj@shanghaitech.edu.cn.
Cao Y; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China. Electronic address: caoyj@nankai.edu.cn.
Zhang H; State Key Laboratory of Medicinal Chemical Biology, 94 Weijin Road, Tianjin, 300071, China; College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, 300071, China. Electronic address: hongkai@nankai.edu.cn.

Biochem Biophys Res Commun ; 509(4): 954-959, 2019 02 19.

Article em En | MEDLINE | ID: mdl-30648553

Assuntos

Descoberta de Drogas; Canal de Potássio Kv1.3/antagonistas & inibidores; Peptídeos/análise; Venenos de Escorpião/química; Animais; Comunicação Autócrina; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Escorpiões/patogenicidade

Palavras-chave

Autocrine-based selection; Kv1.3 ion channel; Next generation sequencing; Venom peptide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Venenos de Escorpião / Canal de Potássio Kv1.3 / Descoberta de Drogas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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