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Are glutamate transporters neuroprotective or neurodegenerative during cerebral ischemia?
J Mol Med (Berl); 97(3): 281-289, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30675649
ABSTRACT
The accumulation of glutamate (Glu) in the synaptic cleft during cerebral ischemia triggers the death of neurons, causing mental or physical handicap. However, the mechanisms of the alteration in Glu homeostasis and the imbalance between the release and clearance of Glu in ischemia are not yet completely understood. Additionally, the role of Glu transporters in regulating Glu concentration in the synaptic cleft is controversial. This review aims to provide readers with an in-depth understanding of Glu transporters in the early or later stages of ischemic events, or in mild or severe cerebral ischemia via alteration of Glu transporter expression, reversal of Glu transporters function, and trafficking between membrane and cytoplasm, to further clarify whether the Glu transporters are neuroprotective or neurodegenerative during cerebral ischemia. We provide the insights for deeper understanding of the mechanism of Glu transporters regulation after different periods and severities of cerebral ischemia.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: J Mol Med (Berl) Assunto da revista: Biologia Molecular / Genética Médica Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China