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Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus.
Legge, Alexandra; Kirkland, Susan; Rockwood, Kenneth; Andreou, Pantelis; Bae, Sang-Cheol; Gordon, Caroline; Romero-Diaz, Juanita; Sanchez-Guerrero, Jorge; Wallace, Daniel J; Bernatsky, Sasha; Clarke, Ann E; Merrill, Joan T; Ginzler, Ellen M; Fortin, Paul; Gladman, Dafna D; Urowitz, Murray B; Bruce, Ian N; Isenberg, David A; Rahman, Anisur; Alarcón, Graciela S; Petri, Michelle; Khamashta, Munther A; Dooley, M A; Ramsey-Goldman, Rosalind; Manzi, Susan; Steinsson, Kristjan; Zoma, Asad A; Aranow, Cynthia; Mackay, Meggan; Ruiz-Irastorza, Guillermo; Lim, S Sam; Inanc, Murat; van Vollenhoven, Ronald F; Jonsen, Andreas; Nived, Ola; Ramos-Casals, Manuel; Kamen, Diane L; Kalunian, Kenneth C; Jacobsen, Soren; Peschken, Christine A; Askanase, Anca; Hanly, John G.
Afiliação
  • Legge A; Dalhousie University, Halifax, Nova Scotia, Canada.
  • Kirkland S; Dalhousie University, Halifax, Nova Scotia, Canada.
  • Rockwood K; Dalhousie University, Halifax, Nova Scotia, Canada.
  • Andreou P; Dalhousie University, Halifax, Nova Scotia, Canada.
  • Bae SC; Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea.
  • Gordon C; University of Birmingham, Birmingham, UK.
  • Romero-Diaz J; Instituto Nacional de Ciencias Medicas y Nutrición, Mexico City, Mexico.
  • Sanchez-Guerrero J; Instituto Nacional de Ciencias Medicas y Nutrición, Mexico City, Mexico.
  • Wallace DJ; Cedars-Sinai Medical Center and David Geffen School of Medicine at University of California, Los Angeles.
  • Bernatsky S; McGill University, Montreal, Quebec, Canada.
  • Clarke AE; University of Calgary, Calgary, Alberta, Canada.
  • Merrill JT; Oklahoma Medical Research Foundation, Oklahoma City.
  • Ginzler EM; SUNY Downstate Medical Center, Brooklyn, New York.
  • Fortin P; CHU de Québec et Université Laval, Quebec City, Canada.
  • Gladman DD; Toronto Western Hospital and University of Toronto, Ontario, Canada.
  • Urowitz MB; Toronto Western Hospital and University of Toronto, Ontario, Canada.
  • Bruce IN; University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK.
  • Isenberg DA; University College London, London, UK.
  • Rahman A; University College London, London, UK.
  • Alarcón GS; University of Alabama at Birmingham.
  • Petri M; Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Khamashta MA; St Thomas' Hospital, King's College London School of Medicine, London, UK.
  • Dooley MA; University of North Carolina, Chapel Hill.
  • Ramsey-Goldman R; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • Manzi S; Allegheny Health Network, Pittsburgh, Pennsylvania.
  • Steinsson K; Landspitali University Hospital, Reykjavik, Iceland.
  • Zoma AA; Hairmyres Hospital, East Kilbride, Scotland, UK.
  • Aranow C; Feinstein Institute for Medical Research, Manhasset, New York.
  • Mackay M; Feinstein Institute for Medical Research, Manhasset, New York.
  • Ruiz-Irastorza G; Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain.
  • Lim SS; Emory University School of Medicine, Atlanta, Georgia.
  • Inanc M; Istanbul University, Istanbul, Turkey.
  • van Vollenhoven RF; Karolinska Institute, Stockholm, Sweden.
  • Jonsen A; Lund University, Lund, Sweden.
  • Nived O; Lund University, Lund, Sweden.
  • Ramos-Casals M; Hospital Clínic de Barcelona, Barcelona, Spain.
  • Kamen DL; Medical University of South Carolina, Charleston.
  • Kalunian KC; University of California San Diego School of Medicine, La Jolla.
  • Jacobsen S; Copenhagen University Hospital, Copenhagen, Denmark.
  • Peschken CA; University of Manitoba, Winnipeg, Manitoba, Canada.
  • Askanase A; Hospital for Joint Diseases, New York University, New York.
  • Hanly JG; Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.
Arthritis Rheumatol ; 71(8): 1297-1307, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30771242
ABSTRACT

OBJECTIVE:

To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).

METHODS:

For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.

RESULTS:

In the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.

CONCLUSION:

The SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Medição de Risco / Fragilidade / Lúpus Eritematoso Sistêmico Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Arthritis Rheumatol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Canadá

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Medição de Risco / Fragilidade / Lúpus Eritematoso Sistêmico Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Arthritis Rheumatol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Canadá