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Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children.
J Int Med Res ; 47(4): 1696-1704, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30803280
ABSTRACT

OBJECTIVE:

To investigate the association between single nucleotide polymorphisms (SNPs) in six candidate genes (enamelin [ ENAM]; tuftelin 1 [ TUFT1]; matrix metallopeptidase 13 [ MMP13]; interleukin 1 beta [ IL1B]; interleukin 10 [ IL10]; interleukin 1 receptor antagonist [ IL1RN]) and dental caries in children from northwest China.

METHODS:

This case-control study enrolled children (12-15 years) who underwent routine dental examinations. The children were divided into two groups based on the presence of dental caries. A saliva sample was collected and seven SNPs (rs3806804A/G in ENAM, rs3811411T/G in TUFT1, rs2252070A/G and rs597315A/T in MMP13, rs1143627C/T in IL1B, rs1800872A/C in IL10 and rs956730G/A in IL1RN) were genotyped.

RESULTS:

A total of 357 children were enrolled in the study: 161 with dental caries and 196 without dental caries. No significant difference was found in the alleles and genotypes of five genes ( ENAM, TUFT1, MMP13, IL10 and IL1RN) between those with and without dental caries. A significant relationship was found between the IL1B rs1143627C/T polymorphism and dental caries susceptibility with those carrying the rs1143627CT genotype having a lower risk of dental caries compared with those carrying the CC genotype (odds ratio 0.557; 95% confidence interval 0.326, 0.952).

CONCLUSION:

The IL1B rs1143627C/T polymorphism may be associated with dental caries susceptibility in children from northwest China.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Proteínas da Matriz Extracelular / Interleucina-10 / Polimorfismo de Nucleotídeo Único / Cárie Dentária / Proteínas do Esmalte Dentário / Metaloproteinase 13 da Matriz / Proteína Antagonista do Receptor de Interleucina 1 / Interleucina-1beta Tipo de estudo: Estudo de casos e controles Aspecto clínico: Etiologia / Prognóstico Limite: Adolescente / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: J Int Med Res Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China