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[Differential expression of lncRNA in patients with coronary artery disease plus clopidogrel resistance].
Zhong Nan Da Xue Xue Bao Yi Xue Ban; 44(1): 9-13, 2019 Jan 28.
Artigo em Chinês | MEDLINE | ID: mdl-30837396

OBJECTIVE:

To explore differential expression of long non-coding RNA (lncRNA) in patients with coronary artery disease plus clopidogrel resistance.
 Methods: Patients underwent percutaneous coronary intervention (PCI) and treated with clopidogrel were recruited, and their clinical data and blood samples were collected. Patients were divided into a clopidogrel sensitive group and a clopidogrel resistance group according to platelet aggregation rate. lncRNA microarray and real-time RT-PCR were performed in 5 and 34 patients in each group, respectively.
 Results: lncRNA microarray showed that 11 lncRNAs in peripheral leukocytes were up-regulated and 8 lncRNAs were down-regulated in clopidogrel resistant group. Real-time PCR indicated that two lncRNAs (NONHSAT083775.2 and NONHSAT107804.2) in leukocytes were up-regulated and one lncRNA (NONHSAT133455.2) was down-regulated in the clopidogrel resistant group compared with the clopidogrel sensitive group, consistent with the results of lncRNA microarray.
 Conclusion: Clopidogrel resistance is associated with the up-regulation of lncRNA NONHSAT083775.2 and NONHSAT107804.2 and the down-regulation of NONHSAT133455.2.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Intervenção Coronária Percutânea Limite: Humanos Idioma: Chinês Revista: Zhong Nan Da Xue Xue Bao Yi Xue Ban Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: China