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Association of body mass and systemic immune-inflammation indices with endocrine therapy resistance in luminal breast cancers.
J Int Med Res ; 47(5): 1936-1947, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30843447
ABSTRACT

OBJECTIVE:

To explore correlations between body mass index (BMI), preoperative systemic immune-inflammation index (SII) and endocrine therapy resistance, and evaluate BMI and SII as predictors of resistance, in patients with luminal breast cancer.

METHODS:

This retrospective study included patients with luminal breast cancer who underwent endocrine therapy at Hebei General Hospital. Relationships between BMI and SII subgroups, and clinicopathological parameters were analysed using χ2-tests. Disease-free survival was assessed using Log-rank statistics. Multivariate analysis of factors related to disease progression were analysed using Cox proportional hazards model.

RESULTS:

Out of 161 patients, those with normal BMI and low SII had significantly lower endocrine resistance rates versus those with high BMI and SII, and BMI was significantly positively correlated with SII. High BMI or SII was associated with significantly lower disease-free survival rates. Hazard ratios for disease progression risk were 6.036, 3.508 and 1.733, for SII, BMI and TNM stage, respectively.

CONCLUSION:

In patients with luminal breast cancer, high BMI (>23 kg/m2) and SII (>518 × 109/L) levels may predict high endocrine resistance rates. BMI, SII and TNM stage were independent prognostic factors for endocrine therapy resistance.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Peso Corporal / Neoplasias da Mama / Resistencia a Medicamentos Antineoplásicos / Hormônios / Inflamação Aspecto clínico: Etiologia / Predição / Prognóstico / Terapia Limite: Feminino / Humanos / Meia-Idade Idioma: Inglês Revista: J Int Med Res Ano de publicação: 2019 Tipo de documento: Artigo