Studies on the L-2-hydroxy-acid oxidase 2 catalyzed metabolism of S-mandelic acid and its analogues.

Zhang, Yang; Su, Chen; Lei, Jinxiu; Chen, Lu; Hu, Haihong; Zeng, Su; Yu, Lushan

Zhang, Yang; Su, Chen; Lei, Jinxiu; Chen, Lu; Hu, Haihong; Zeng, Su; Yu, Lushan.

Afiliação

Zhang Y; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Su C; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Lei J; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Chen L; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Hu H; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Zeng S; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yu L; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: yuls@zju.edu.cn.

Drug Metab Pharmacokinet ; 34(3): 187-193, 2019 Jun.

Article em En | MEDLINE | ID: mdl-30876779

Assuntos

Oxirredutases do Álcool/metabolismo; Ácidos Mandélicos/metabolismo; Oxirredutases do Álcool/genética; Animais; Biocatálise; Clonagem Molecular; Escherichia coli/genética; Expressão Gênica; Humanos; Cinética; Ácidos Mandélicos/química; Ratos; Especificidade da Espécie; Estereoisomerismo

Palavras-chave

Cloning and expression; Long-chain 2-hydroxy-acid oxidase 2; Mandelic acid; Mandelic acid analogues; Species difference; Stereoselectivity metabolism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases do Álcool / Ácidos Mandélicos Limite: Animals / Humans Idioma: En Revista: Drug Metab Pharmacokinet Assunto da revista: FARMACOLOGIA / METABOLISMO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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