Effect of EP1 Receptor Antagonist on Transient Lower Esophageal Sphincter Relaxations in Humans.
Digestion
; 101(3): 270-278, 2020.
Article
em En
| MEDLINE
| ID: mdl-30897584
ABSTRACT
BACKGROUND/AIMS:
Transient lower esophageal sphincter relaxations (TLESRs) are the major cause of gastroesophageal reflux. Recently, an EP1 receptor antagonist, ONO-8539, showed the reduction of TLESRs in monkeys. However, its effect on TLESRs in humans remains unclear. This study investigated the effect of ONO-8539 on postprandial TLESRs in healthy male subjects.METHODS:
Twenty-seven subjects participated in this placebo-controlled, cross-over study. The subjects received either placebo or ONO-8539 (450 mg) after a standardized breakfast. A 30-min basal recording was performed 4 h after drug administration. Subsequently, TLESR recordings were performed after a high-fat test meal for 3 h. The examination was repeated at least 7 days from the first evaluation for washout.RESULTS:
Thirteen patients were ultimately analyzed. The basal lower esophageal sphincter pressure was not different between the 2 groups (16.3 and 18.0 mm Hg for placebo and ONO-8539, respectively; p = 0.88). ONO-8539 significantly reduced the number of TLESRs from 15.0 to 12.0 for 3 h (p < 0.05). The proportion of terminating events of TLESRs was significantly different between the 2 groups (p < 0.05). No events and swallowing terminated more TLESRs with ONO-8539 than with placebo.CONCLUSIONS:
ONO-8539 suppressed TLESRs mildly. EP1 receptor may be involved with the mechanism of human TLESRs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Benzoatos
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Refluxo Gastroesofágico
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Esfíncter Esofágico Inferior
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Receptores de Prostaglandina E Subtipo EP1
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Indenos
/
Relaxamento Muscular
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
/
Male
Idioma:
En
Revista:
Digestion
Ano de publicação:
2020
Tipo de documento:
Article