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Cause or effect? Interpreting emerging evidence for dysbiosis in systemic sclerosis.
Arthritis Res Ther ; 21(1): 81, 2019 03 27.
Artigo em Inglês | MEDLINE | ID: mdl-30917857
ABSTRACT
Systemic sclerosis (SSc) is an immune-mediated fibrotic disease affecting skin, lung and gut which are all sites with an established microbiome. Altered microbial flora may occur and contribute to the initiation, progression or severity of disease. However, dysbiosis could also be secondary to the disease or immunosuppressive therapy. Here we consider how lessons could be learned from gastroenterology, a speciality where dysbiosis is strongly implicated in disease mechanism and treatment. This could be highly relevant to molecular pathology of skin in SSc and could drive the inflammatory gene signature observed in some skin biopsies.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Escleroderma Sistêmico / Microbiota / Microbioma Gastrointestinal Limite: Humanos Idioma: Inglês Revista: Arthritis Res Ther Assunto da revista: Reumatologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Reino Unido