[The prediction of the spectrum of biological activity and antimicrobial properties of diaminoazoles]. / Prognozirovanie spektra biologicheskoi aktivnosti i antimikrobnye svoistva diaminoazolov.
Biomed Khim
; 65(2): 99-102, 2019 Feb.
Article
em Ru
| MEDLINE
| ID: mdl-30950814
ABSTRACT
The work is devoted to predicting and studying biological properties of N-substituted analogs of 3,5-diamino-1,2,4-thiadiazole, which, in their turn, include in the composition of many drugs that exhibit a wide range of pharmacological actions. For searching of new alternative drugs with an antibacterial activity, but lacking resistance of microorganism strains to them, a computer screening of 2N-alkyl-substituted 5-amino-3-imino-1,2,4-thiadiazolines previously synthesized by us was carried out. The prediction of the spectrum of biological activity, as well as the determination of the probable toxicity of these compounds, was performed using the freely available computer programs PASS, Anti-Bac-Pred, and GUSAR. The study of the antibacterial activity in vitro against gram-positive (Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus epidermidis) and gram-negative (Escherichia coli, Pseudomonas aeruginosae) bacterial strains was performed by the disco-diffusion method. Experimental data roughly correspond to the predictions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
Ru
Revista:
Biomed Khim
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Federação Russa
País de publicação:
FEDERAÇÃO RUSSA
/
RU
/
RUSIA
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RUSSIA