Structural basis of specific H2A K13/K15 ubiquitination by RNF168.

Horn, Velten; Uckelmann, Michael; Zhang, Heyi; Eerland, Jelmer; Aarsman, Ivette; le Paige, Ulric B; Davidovich, Chen; Sixma, Titia K; van Ingen, Hugo

Horn, Velten; Uckelmann, Michael; Zhang, Heyi; Eerland, Jelmer; Aarsman, Ivette; le Paige, Ulric B; Davidovich, Chen; Sixma, Titia K; van Ingen, Hugo.

Afiliação

Horn V; Department of Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Uckelmann M; NMR Group, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, the Netherlands.
Zhang H; Division of Biochemistry and Oncode Institute, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, the Netherlands.
Eerland J; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, 23 Innovation Walk, Clayton, VIC, 3800, Australia.
Aarsman I; Department of Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
le Paige UB; NMR Group, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH, Utrecht, the Netherlands.
Davidovich C; Department of Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.
Sixma TK; Division of Biochemistry and Oncode Institute, Netherlands Cancer Institute, P.O. Box 90203, 1006 BE, Amsterdam, the Netherlands.
van Ingen H; Department of Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, the Netherlands.

Nat Commun ; 10(1): 1751, 2019 04 15.

Article em En | MEDLINE | ID: mdl-30988309

Assuntos

Histonas/química; Ubiquitina-Proteína Ligases/química; Diferenciação Celular; Reparo do DNA; Histonas/metabolismo; Humanos; Modelos Moleculares; Domínios Proteicos; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitina-Proteína Ligases/fisiologia; Ubiquitinação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Ubiquitina-Proteína Ligases Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

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