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Cardiovascular biomarkers in dogs with systemic inflammatory response syndrome.
J Vet Emerg Crit Care (San Antonio) ; 29(3): 256-263, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31034737
ABSTRACT

OBJECTIVE:

To measure plasma N-terminal fragments of pro-B-type natriuretic peptides (NT-proBNP) and cardiac troponin T (cTnT) concentration in hospitalized dogs and relate these markers to underlying conditions and evaluate their potential as prognostic markers in dogs with systemic inflammatory response syndrome (SIRS).

DESIGN:

Prospective, observational, clinical study.SETTING: Emergency department of a university teaching hospital.ANIMALS: Sixty-nine dogs with SIRS examined in the emergency department were prospectively studied. Patient age ranged from 5 months to 15 years, and weight ranged from 5.5 to 75 kg.

MEASUREMENTS AND MAIN RESULTS:

Blood samples were obtained at presentation, during hospitalization until discharge or death, and at a "control" visit (T1m) at least 1 month after hospital discharge. NT-proBNP was assayed with a commercially available canine ELISA, while cTnT was measured with an automated immunoassay previously used in dogs. A correlation procedure, mixed procedure on a linear model, and a logistic procedure were performed. Forty-four patients survived, 19 of which had control visits. cTnT concentrations were significantly higher than T0 and T1m at T12, T24, and T72. In 28 dogs, cTnT was detected during hospitalization, but cTnT was not detected in any dog at the control visits. Higher concentrations of cTnT were negatively associated with survival, irrespective of disease category. NT-proBNP concentrations were significantly higher than T0, T6, T12, and T1m at T24, T72, and T120, but were not associated with survival.

CONCLUSIONS:

NT-proBNP and cTnT increased significantly in dogs with SIRS, regardless of the underlying disease process. Nonsurvivors displayed significantly higher cTnT concentrations during hospitalization.
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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Biomarcadores / Síndrome de Resposta Inflamatória Sistêmica / Troponina T / Peptídeo Natriurético Encefálico / Doenças do Cão Aspecto clínico: Prognóstico Limite: Animais Idioma: Inglês Revista: J Vet Emerg Crit Care (San Antonio) Assunto da revista: Medicina de Emergência / Medicina Veterinária / Terapia Intensiva Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Bélgica