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Metastasis Organotropism: Redefining the Congenial Soil.
Dev Cell; 49(3): 375-391, 2019 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-31063756
Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as "organotropism." Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Dev Cell Assunto da revista: Embriologia Ano de publicação: 2019 Tipo de documento: Artigo