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Economic burden of inpatients infected with Klebsiella pneumoniae carbapenemase.
Einstein (Sao Paulo) ; 17(4): eGS4444, 2019 May 16.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31116310


To estimate the direct medical costs of drug therapy of Klebsiella pneumoniae carbapenemase (KPC) infection patients in hospital-based context.


A cost-of-illness study conducted with a prospective cohort design with hospitalized adults infected by KPC. Data collection was performed using an instrument composed of sociodemographic data, clinical and prescription medication. Estimates of the direct costs associated to each treatment were derived from the payer's perspective, in the case of federal public hospitals from Brazil, and included only drug costs. These costs were based on the average price available at the Brazilian Price Database Health. No discount rate was used for the cost of drugs. The costs are calculate in American Dollar (US$).


A total of 120 inpatients participated of this study. The total drug cost of these inpatients was US$ 367,680.85. The systemic antimicrobial group was responsible for 59.5% of total costs. The direct drug cost per patients infected by KPC was conservatively estimated at nearly US$ 4,100.00, and about of 60% of costs occurred during the period of infection.


The findings of our study indicate a thoughtful economic hazard posed by KPC that all healthcare sectors have to face. The increasing worldwide incidence of these bacteria represents a growing burden that most health systems are unable to deal with. There is an imperative need to develop protocols and new antimicrobials to treatment of KPC, aiming to rearrange resources to increase the effectiveness of healthcare services.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Infecções por Klebsiella / Hospitalização / Klebsiella pneumoniae / Antibacterianos Tipo de estudo: Avaliação econômica em saúde Aspecto clínico: Etiologia Limite: Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês / Português Revista: Einstein (Sao Paulo) Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil