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Reflectance confocal microscopy-guided carbon dioxide laser ablation of low-risk basal cell carcinomas: A prospective study.
Navarrete-Dechent, Cristian; Cordova, Miguel; Liopyris, Konstantinos; Yélamos, Oriol; Aleissa, Saud; Hibler, Brian; Sierra, Heidy; Sahu, Aditi; Blank, Nina; Rajadhyaksha, Milind; Rossi, Anthony.
Afiliação
  • Navarrete-Dechent C; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Cordova M; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Liopyris K; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Yélamos O; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
  • Aleissa S; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Hibler B; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Dermatology, Weill Cornell Medical College, New York, New York.
  • Sierra H; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Computer Science and Engineering, University of Puerto Rico Mayaguez, Mayaguez, Puerto Rico.
  • Sahu A; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Blank N; Department of Dermatology, Weill Cornell Medical College, New York, New York.
  • Rajadhyaksha M; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
  • Rossi A; Dermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Dermatology, Weill Cornell Medical College, New York, New York. Electronic address: rossia@mskcc.org.
J Am Acad Dermatol ; 81(4): 984-988, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31202871
ABSTRACT

BACKGROUND:

Basal cell carcinoma (BCC) treatment modalities can be stratified by tumor subtype and recurrence risk. The main limitation of nonsurgical treatment modalities is the lack of histopathologic confirmation. Reflectance confocal microscopy (RCM) is a noninvasive imaging device that provides quasihistologic images.

OBJECTIVE:

To evaluate the feasibility and efficacy of RCM-guided carbon dioxide (CO2) laser ablation of low-risk BCCs.

METHODS:

Prospective study with biopsy specimen-proven low-risk BCCs imaged with RCM. RCM was performed on these sites before and after ablation. If residual tumor was found, a new series of laser passes were performed. The patients were then monitored for recurrence clinically and with RCM.

RESULTS:

Twenty-two tumor sites in 9 patients (5 men, 4 women) were imaged and treated. Median age was 59 ± 12.9 years (range, 30-74 years). Mean tumor size was 7.7 mm (range, 5-10 mm). Residual tumor was identified in 5 of 22 cases (22.7%) under RCM on immediate first-pass postablation sites, prompting additional laser passes. Median follow-up was 28.5 months (range, 22-32 months) with no recurrences found.

CONCLUSIONS:

Addition of RCM to laser ablation workflow can detect subclinical persistent tumor after initial ablation and may serve as an aid to increase the efficacy of laser ablation.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar Tema em saúde: Objetivo 9: Redução de doenças não transmissíveis / Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma Basocelular / Terapia a Laser / Lasers de Gás / Recidiva Local de Neoplasia Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Am Acad Dermatol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Chile

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar Tema em saúde: Objetivo 9: Redução de doenças não transmissíveis / Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma Basocelular / Terapia a Laser / Lasers de Gás / Recidiva Local de Neoplasia Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Am Acad Dermatol Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Chile