Your browser doesn't support javascript.
loading
Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history.
Jenkins, Mark A; Win, Aung K; Dowty, James G; MacInnis, Robert J; Makalic, Enes; Schmidt, Daniel F; Dite, Gillian S; Kapuscinski, Mirosl; Clendenning, Mark; Rosty, Christophe; Winship, Ingrid M; Emery, Jon D; Saya, Sibel; Macrae, Finlay A; Ahnen, Dennis J; Duggan, David; Figueiredo, Jane C; Lindor, Noralane M; Haile, Robert W; Potter, John D; Cotterchio, Michelle; Gallinger, Steven; Newcomb, Polly A; Buchanan, Daniel D; Casey, Graham; Hopper, John L.
Afiliação
  • Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia. m.jenkins@unimelb.edu.au.
  • Win AK; Centre for Cancer Research, The University of Melbourne, Parkville, VIC, Australia. m.jenkins@unimelb.edu.au.
  • Dowty JG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • MacInnis RJ; Centre for Cancer Research, The University of Melbourne, Parkville, VIC, Australia.
  • Makalic E; Genetic Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Schmidt DF; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Dite GS; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Kapuscinski M; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
  • Clendenning M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Rosty C; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Winship IM; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Emery JD; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
  • Saya S; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia.
  • Macrae FA; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia.
  • Ahnen DJ; Envoi Specialist Pathologists, Herston, QLD, Australia.
  • Duggan D; School of Medicine, University of Queensland, Herston, QLD, Australia.
  • Figueiredo JC; Genetic Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Lindor NM; Department of Medicine, The University of Melbourne, Parkville, VIC, Australia.
  • Haile RW; Department of General Practice, Centre for Cancer Research, University of Melbourne, Parkville, VIC, Australia.
  • Potter JD; The Primary Care Unit, Department of Public Health & Primary Care, University of Cambridge, Cambridge, UK.
  • Cotterchio M; Department of General Practice, Centre for Cancer Research, University of Melbourne, Parkville, VIC, Australia.
  • Gallinger S; The Primary Care Unit, Department of Public Health & Primary Care, University of Cambridge, Cambridge, UK.
  • Newcomb PA; Genetic Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Buchanan DD; Department of Medicine, The University of Melbourne, Parkville, VIC, Australia.
  • Casey G; Colorectal Medicine and Genetics, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Hopper JL; University of Colorado School of Medicine, Denver, CO, USA.
Fam Cancer ; 18(4): 389-397, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31209717
ABSTRACT
Before SNP-based risk can be incorporated in colorectal cancer (CRC) screening, the ability of these SNPs to estimate CRC risk for persons with and without a family history of CRC, and the screening implications need to be determined. We estimated the association with CRC of a 45 SNP-based risk using 1181 cases and 999 controls, and its correlation with CRC risk predicted from detailed family history. We estimated the predicted change in the distribution across predefined risk categories, and implications for recommended screening commencement age, from adding SNP-based risk to family history. The inter-quintile risk ratio for colorectal cancer risk of the SNP-based risk was 3.28 (95% CI 2.54-4.22). SNP-based and family history-based risks were not correlated (r = 0.02). For persons with no first-degree relatives with CRC, screening could commence 4 years earlier for women (5 years for men) in the highest quintile of SNP-based risk. For persons with two first-degree relatives with CRC, screening could commence 16 years earlier for men and women in the highest quintile, and 7 years earlier for the lowest quintile. This 45 SNP panel in conjunction with family history, can identify people who could benefit from earlier screening. Risk reclassification by 45 SNPs could inform targeted screening for CRC prevention, particularly in clinical genetics settings when mutations in high-risk genes cannot be identified. Yet to be determined is cost-effectiveness, resources requirements, community, patient and clinician acceptance, and feasibility with potentially ethical, legal and insurance implications.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar Tema em saúde: Objetivo 9: Redução de doenças não transmissíveis / Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Polimorfismo de Nucleotídeo Único Tipo de estudo: Ensaio clínico controlado / Estudo de rastreamento Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Fam Cancer Assunto da revista: Neoplasias Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Austrália

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar Tema em saúde: Objetivo 9: Redução de doenças não transmissíveis / Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Polimorfismo de Nucleotídeo Único Tipo de estudo: Ensaio clínico controlado / Estudo de rastreamento Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Fam Cancer Assunto da revista: Neoplasias Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Austrália