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SATB1 Expression of Colorectal Adenomatous Polyps is Higher than that of Colorectal Carcinomas.
Yalcin, Gulsum S; Gonultas, Mehmet A; Hucumenoglu, Sema; Simsek, Gulcin; Pekcici, Mevlut R.
Afiliação
  • Yalcin GS; Pathology Department, Kecioren Training and Research Hospital, University of Health Sciences.
  • Gonultas MA; Pathology Department.
  • Hucumenoglu S; Pathology Department.
  • Simsek G; Pathology Department, Kecioren Training and Research Hospital, University of Health Sciences.
  • Pekcici MR; General Surgery Department, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Appl Immunohistochem Mol Morphol ; 28(7): 532-537, 2020 08.
Article em En | MEDLINE | ID: mdl-31290787
ABSTRACT
"Special AT-rich sequence-binding protein-1" (SATB1) is a global genome organizer and is found to have effects on carcinogenesis and progression of various malignancies including colorectal carcinoma (CRC). We aimed to investigate the expression of SATB1 in CRC and colorectal adenomatous polyps (CAP), the correlation between clinicopathologic parameters, and overall survival. We examined 227 CRCs and 129 CAPs. SATB1 protein expression was evaluated by immunohistochemistry. We found higher SATB1 expression in adenomatous epithelium than in CRC tissues (55.0% vs. 42.7%, respectively) (P<0.05). None of the adjacent normal colorectal mucosa stained positive in CRC cases, and only one of the adjacent normal mucosa of the CAP cases was positive. SATB1 expression of left-sided CRC was higher than that of right-sided CRC (46.3% vs. 28.6%, respectively) (P<0.05), and SATB1 expression of conventional adenocarcinomas was higher than that of mucinous carcinomas (45.5% vs. 6.3%, respectively) (P<0.05). SATB1 expression was higher in CAPs consisting of high-grade dysplasia than in polyps with low-grade dysplasia (77.8% vs. 51.4%) (P<0.05). SATB1 expression did not correlate with patients' overall survival. In conclusion, due to the higher expression of SATB1 in CAP than in CRC, we think SATB1 may have a role in the early stages of carcinogenesis of CRCs. This is the first study investigating SATB1 expression in CAPs. Besides this is the first report that shows different SATB1 expressions in conventional colorectal adenocarcinoma and mucinous carcinoma, and also in right-sided and left-sided CRC. Our results, with supporting new studies, can provide SATB1 as a possible candidate for targeted therapy for CRC patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Polipose Adenomatosa do Colo / Proteínas de Ligação à Região de Interação com a Matriz Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Appl Immunohistochem Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Ano de publicação: 2020 Tipo de documento: Article País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Polipose Adenomatosa do Colo / Proteínas de Ligação à Região de Interação com a Matriz Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Appl Immunohistochem Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Ano de publicação: 2020 Tipo de documento: Article País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA