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Insights into Computational Drug Repurposing for Neurodegenerative Disease.
Trends Pharmacol Sci ; 40(8): 565-576, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31326236
ABSTRACT
Computational drug repurposing has the ability to remarkably reduce drug development time and cost in an era where these factors are prohibitively high. Several examples of successful repurposed drugs exist in fields such as oncology, diabetes, leprosy, inflammatory bowel disease, among others, however computational drug repurposing in neurodegenerative disease has presented several unique challenges stemming from the lack of validation methods and difficulty in studying heterogenous diseases of aging. Here, we examine existing approaches to computational drug repurposing, including molecular, clinical, and biophysical methods, and propose data sources and methods to advance computational drug repurposing in neurodegenerative disease using Alzheimer's disease as an example.

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Idioma: Inglês Revista: Trends Pharmacol Sci Ano de publicação: 2019 Tipo de documento: Artigo